Why a Science Hub?
We believe in transparency and education. You deserve to know what’s in Alisera, and how each ingredient has been studied. On this page, you’ll find the four core areas of support and the key research behind them.
Why a Science Hub?
We believe in transparency and education. You deserve to know what’s in Alisera, and how each ingredient has been studied. On this page, you’ll find the four core areas of support and the key research behind them.
Alisera’s Core Benefits
Supports Thermoregulatory Comfort
What it means for you:
Some of the most disruptive experiences during menopause involve sudden changes in body temperature.
Research on key botanical ingredients in Alisera has explored their role in supporting the body’s natural thermoregulatory balance, helping maintain greater day-to-day comfort.
What the research says:
- EstroG-100® (514 mg) – In randomized, placebo-controlled trials lasting 8–12 weeks, this ingredient was associated with statistically significant reductions in hot flash frequency and severity [1][3][4].
- Sage leaf extract (400 mg) –Clinical research suggests sage may support thermoregulatory comfort and help maintain healthy sweat response in menopausal women [3][4][5].
Supports Sleep Quality
What it means for you:
Sleep disruption is one of the most commonly reported changes during menopause. Hormonal shifts affect the body's ability to fall and stay asleep.
Research on key ingredients in Alisera has explored their role in supporting the body's natural sleep-wake cycle, helping maintain more restful and restorative sleep.
What the research says:
- Sensoril® (300 mg) — In a randomized, double-blind, placebo-controlled study, ashwagandha extract supported sleep quality in healthy adults over 8 weeks. [8]
- Affron® (28 mg) — Clinical research on saffron extract in perimenopausal women showed improvements in climacteric symptoms including sleep-related disturbances over 12 weeks. [7]
- EstroG-100® (514 mg) — Multiple randomized, placebo-controlled trials demonstrated improvements in sleep disturbances as part of overall menopausal symptom reduction, measured by the Kupperman Menopausal Index. [1,2]
- L-Theanine — Supports relaxation and sleep quality without sedation by increasing alpha-wave brain activity and modulating GABA and serotonin signaling. [10,11]
Supports Emotional Balance & Stress Resilience
What it means for you:
Hormonal changes during menopause can influence mood, emotional stability, sleep quality, and the body’s response to stress.
Ingredients in Alisera have been studied for their role in supporting neurotransmitter balance, calm focus, and the body’s natural stress response.
What the research says:
- Affron® (28 mg) – In a 12-week randomized, double-blind, placebo-controlled trial in perimenopausal women, this ingredient was associated with improvements in mood-related menopausal symptoms [6][7].
- Sensoril® (300 mg) – In an 8-week double-blind clinical study, this ingredient was associated with reduced cortisol levels and improved sleep quality in adults [8][9].
- L-Theanine (150 mg) – In a 4-week clinical trial in healthy adults, L-Theanine was associated with reduced stress markers and promotion of a relaxed yet alert mental state [10].
Supports Bone & Heart Health
What it means for you:
After menopause, hormonal changes can influence both bone health and cardiovascular wellness.
Alisera includes nutrients and botanicals that have been studied for their roles in supporting calcium metabolism, vascular health, and long-term structural wellness.
What the research says:
- Vitamin D3 (50 mcg) – Supports calcium absorption, an essential process in maintaining bone structure [12].
- Vitamin K2 (MK-7) (120 mcg) – Helps activate osteocalcin, supporting proper calcium utilization in bone tissue [12].
Clinical research in postmenopausal women has shown associations between adequate vitamin D and K status and improvements in bone mineral density and bone health markers.
Saffron and L-theanine have also been studied for their potential influence on stress-related cardiovascular markers and overall metabolic balance [6][10][11].
Supports Hormonal Balance & Daily Well-Being
What it means for you:
Menopause brings a shift in hormonal patterns that can affect multiple areas of life — energy, mood, sleep quality, resilience, and vaginal comfort.
Research on key ingredients in Alisera has explored their role in supporting the body's hormonal balance and overall well-being during the menopausal transition.
What the research says:
- EstroG-100® (514 mg) – In two separate 12-week, randomized, double-blind, placebo-controlled trials, this ingredient was associated with a statistically significant reduction in total KMI (Kupperman Menopausal Index) scores compared to placebo [1][2].
- Participants reported improvements in hot flashes, sleep quality, fatigue, mood balance, nervousness, and vaginal dryness.
Enhanced Absorption & Utilization
What it means for you:
Most supplements are only as effective as what your body can actually absorb. Formulation quality matters beyond the ingredients themselves.
Research on BioPerine® has explored its role in supporting the bioavailability of co-administered nutrients, helping ensure key ingredients are effectively absorbed and utilized by the body.
What the research says:
- BioPerine® (5 mg) — A pharmacokinetic study in human volunteers demonstrated that piperine significantly enhanced the bioavailability of co-administered nutrients by inhibiting hepatic and intestinal glucuronidation, improving intestinal absorption and systemic retention of active compounds. [13]
How We Chose the Ingredients
Alisera’s formula was built on three simple principles:
- Clinical alignment: Each ingredient is included at doses within clinically studied dosage ranges drawn from human research.
- Synergy: The eight actives are intentionally combined to work together (e.g., Vitamin D3 + K2 for bone support; Sensoril® + L-Theanine for stress and sleep support).
- Purity & consistency: All botanicals are sourced from GMP-certified suppliers. The finished product is tested for potency and quality.
From human clinical research to transparent labeling — every ingredient is chosen with purpose.
How We Chose the Ingredients
Alisera’s formula was built on three simple principles:
- Clinical alignment: Each ingredient is included at doses within clinically studied dosage ranges drawn from human research.
- Synergy: The eight actives are intentionally combined to work together (e.g., Vitamin D3 + K2 for bone support; Sensoril® + L-Theanine for stress and sleep support).
- Purity & consistency: All botanicals are sourced from GMP-certified suppliers. The finished product is tested for potency and quality.
From human clinical research to transparent labeling — every ingredient is chosen with purpose.
Quick Reference Table
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Scientific References
The following peer-reviewed studies informed the ingredient selection and dosage ranges used in the formulation of Alisera.
- Chang A, Kwak BY, Yi K, Kim JS. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. 2012;26(4):510–516. doi:10.1002/ptr.3597.
- Kirubamani H, Ahire P, Stalin C. Evaluation of efficacy and safety of EstroG-100® in alleviating menopausal symptoms in postmenopausal women in India: a prospective, single-center, single-arm, interventional study. J Midlife Health. 2023;14(4):285–290. doi: 10.4103/jmh.jmh_220_23.
- Bommer S, Klein P, Suter A. First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther. 2011;28(6):490–500. doi:10.1007/s12325-011-0027-z.
- Rahte S, Evans R, Eugster PJ, Marcourt L, Wolfender JL, Kortenkamp A, Tasdemir D. Salvia officinalis for hot flushes: towards determination of mechanism of activity and active principles. Planta Med. 2013;79(9):753–760. doi:10.1055/s-0032-1328552.
- Moradi M, Ghavami V, Niazi A, Seraj Shirvan F, Rasa S. The effect of Salvia officinalis on hot flashes in postmenopausal women: a systematic review and meta-analysis. Int J Community Based Nurs Midwifery. 2023;11(3):169–178. doi:10.30476/IJCBNM.2023.97639.2198.
- Hasheminasab FS, Azimi M, Raeiszadeh M. Therapeutic effects of saffron (Crocus sativus L.) on female reproductive system disorders: a systematic review. Phytother Res. 2024;38(6):2832–2846. doi:10.1002/ptr.8186.
- Lopresti AL, Smith SJ. The effects of a saffron extract (affron®) on menopausal symptoms in women during perimenopause: a randomized, double-blind, placebo-controlled study. J Menopausal Med. 2021;27(2):66–78. doi:10.6118/jmm.21002.
- Deshpande A, Irani N, Balkrishnan R, Benny IR. A randomized, double-blind, placebo-controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020; 72:28–36. doi: 10.1016/j.sleep.2020.03.012.
- Gopal S, Ajgaonkar A, Kanchi P, Kaundinya A, Thakare V, Chauhan S, Langade D. Effect of an ashwagandha (Withania somnifera) root extract on climacteric symptoms in women during perimenopause: a randomized, double-blind, placebo-controlled study. J Obstet Gynaecol Res. 2021;47(12):4414–4425. doi:10.1111/jog.15030.
- Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. Nutrients. 2019;11(10):2362. doi:10.3390/nu11102362.
- Meegaswatte H, Speer K, McKune AJ, Naumovski N. Functional foods and nutraceuticals for the management of cardiovascular disease risk in postmenopausal women. Rev Cardiovasc Med. 2024;25(12):460. doi:10.31083/j.rcm2512460.
- Rønn SH, Harsløf T, Oei L, Pedersen SB, Langdahl BL. The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia: a 3-year randomized, placebo-controlled clinical trial. Osteoporos Int. 2021;32(1):185–191. doi:10.1007/s00198-020-05638-z.
- Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353–356. doi:10.1055/s-2006-957450.
